Korean J Ophthalmol.  2016 Oct;30(5):335-343. 10.3341/kjo.2016.30.5.335.

Influence of Myopia on Size of Optic Nerve Head and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography

Affiliations
  • 1Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. eyeyoung@hallym.or.kr
  • 2Bundang Clean Eye Clinic, Seongnam, Korea.
  • 3Somang Ophthalmic Clinic, Incheon, Korea.
  • 4Haenam Kim's Eye Clinic, Haenam, Korea.
  • 5Dain Eye Clinic, Incheon, Korea.
  • 6Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.
  • 7Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea.

Abstract

PURPOSE
To investigate optic nerve head size and retinal nerve fiber layer (RNFL) thickness according to refractive status and axial length.
METHODS
In a cross-sectional study, 252 eyes of 252 healthy volunteers underwent ocular biometry measurement as well as optic nerve head and RNFL imaging by spectral-domain optical coherence tomography. Correlation and linear regression analyses were performed for all subjects. The magnification effect was adjusted by the modified axial length method.
RESULTS
Disc area and spherical equivalent were positively correlated (r = 0.225, r² = 0.051, p = 0.000). RNFL thickness showed significant correlations with spherical equivalent (r = 0.359, r² = 0.129, p = 0.000), axial length (r = -0.262, r² = 0.069, p = 0.000), disc radius (r = 0.359, r² = 0.129, p = 0.000), and radius of the scan circle (r = -0.262, r² = 0.069, p = 0.000). After adjustment for the magnification effect, those relationships were reversed; RNFL thickness showed negative correlation with spherical equivalent and disc radius, and positive correlation with axial length and radius of the scan circle. The distance between the disc margin and the scan circle was closely correlated with RNFL thickness (r = -0.359, r² = 0.129, p = 0.000), which showed a negative correlation with axial length (r = -0.262, r² = 0.069, p = 0.000).
CONCLUSIONS
Optic disc radius and RNFL thickness decreased in more severely myopic eyes, but they increased after adjustment for magnification effect. The error due to the magnification effect and optic nerve head size difference might be factors that should be considered when interpreting optical coherence tomography results.

Keyword

Myopia; Optic nerve; Optical coherence tomography

MeSH Terms

Biometry
Cross-Sectional Studies
Healthy Volunteers
Linear Models
Methods
Myopia*
Nerve Fibers*
Optic Disk*
Optic Nerve*
Radius
Retinaldehyde*
Tomography, Optical Coherence*
Retinaldehyde

Figure

  • Fig. 1 Linear regression analysis of relationships of optic nerve head parameters, radius of scan circle, and peripapillary retinal nerve fiber layer (RNFL) thickness to axial length before and after adjustment for ocular magnification effect. (A) Rim area, (B) disc area, (C) cup area, (D) radius of disc, (E) disc-scan circle distance, and (F) RNFL thickness.

  • Fig. 2 Linear regression analysis of relationships of optic nerve head parameters, radius of scan circle, and peripapillary retinal nerve fiber layer (RNFL) thickness to spherical equivalent before and after adjustment for ocular magnification effect. (A) Rim area, (B) disc area, (C) cup area, (D) radius of disc, (E) disc-scan circle distance, and (F) RNFL thickness. D = diopters.


Cited by  1 articles

Effect of High Myopia on Optic Nerve Head by Confocal Scanning Laser Ophthalmoscopy in Nepalese Eyes
Sameer Bhaila, Sagun Narayan Joshi, Madhu Thapa, Gauri Shankar Shrestha
Korean J Ophthalmol. 2019;33(2):181-188.    doi: 10.3341/kjo.2018.0098.


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