Lab Med Online.  2016 Oct;6(4):193-213. 10.3343/lmo.2016.6.4.193.

Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines Part 2

• Kim S
• Yun YM
• Kim IS
• Song SH
• Woo HI
• Lee KA
• Lee W
• Cho HJ
• Ji M
• Chae HJ
• Lee SY
• Chun S

• KMID: 2353421
• DOI: http://doi.org/10.3343/lmo.2016.6.4.193

Abstract

Pharmacogenetics is a rapidly evolving field and the number of pharmacogenetic tests for clinical use is steadily increasing. However, incorrect or inadequate implementation of pharmacogenetic tests in clinical practice may result in a rise in medical costs and adverse outcomes in patients. This document suggests guidelines for the clinical application, interpretation, and reporting of pharmacogenetic test results based on a literature review and the collection of evidence-based expert opinions. The clinical laboratory practice guidelines encompass the clinical pharmacogenetic tests covered by public medical insurance in Korea. Technical, ethical, and regulatory issues related to clinical pharmacogenetic tests have also been addressed. In particular, this document comprises the following pharmacogenetic tests: CYP2C9 and VKORC1 for warfarin, CYP2C19 for clopidogrel, CYP2D6 for tricyclic antidepressants, codeine, tamoxifen, and atomoxetine, NAT2 for isoniazid, UGT1A1 for irinotecan, TPMT for thiopurines, EGFR for tyrosine kinase inhibitors, ERBB2 (HER2) for erb-b2 receptor tyrosine kinase 2-targeted therapy, and KRAS for anti-epidermal growth factor receptor drugs. These guidelines would help improve the usefulness of pharmacogenetic tests in routine clinical settings.

Keyword

Pharmacogenetics; Genetic testing; Practice guidelines; Clinical laboratory services

MeSH Terms

Antidepressive Agents, Tricyclic
Atomoxetine Hydrochloride
Clinical Laboratory Services
Codeine
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
Expert Testimony
Genetic Testing
Humans
Insurance
Isoniazid
Korea
Pharmacogenetics
Protein-Tyrosine Kinases
Tamoxifen
Warfarin
Antidepressive Agents, Tricyclic
Atomoxetine Hydrochloride
Codeine
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6
Isoniazid
Protein-Tyrosine Kinases
Tamoxifen
Warfarin

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