Korean J Otorhinolaryngol-Head Neck Surg.  2016 Sep;59(9):676-679. 10.3342/kjorl-hns.2016.59.9.676.

Histopathological Evaluation of Collagen Sheet (Permacol®) after Augmentation Rhinoplasty

  • 1Department of Otolaryngology, Bundang CHA Medical Center, CHA University, Seongnam, Korea. jjongmari@nate.com
  • 2Chang Chul ENT Clinic, Seoul, Korea.


In Asian rhinoplasty, allograft materials are often required due to insufficient amount of autologous sources for dorsal augmentation. Nowadays, Silicon and polytetrafluoroethylene are commonly used allograft materials although these can often lead to postoperative complications such as protrusion, migration or infection of implanted graft. Permacol® is a collagen sheet which is indicated for soft tissue reinforcement or repair of the head and face area in plastic and reconstructive surgery. Its clinical safety and stability is well established with low complication rates. However, its histopathology has rarely investigated, especially in human. Thus, we reviewed histopathology of two graft-removal cases of patients who had undergone rhinoplasty using Permacol®. In conclusion, Permacol® can lead to fibrosis of imbedded tissues with or without absorption in long-term follow-up. Although Permacol® is gradually absorbed as time passes, the implanted graft can maintain its volume by replaced fibrotic connective tissues.


Augmentation; Collagen implant; Permacol; Rhinoplasty
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