Transl Clin Pharmacol.  2016 Sep;24(3):124-126. 10.12793/tcp.2016.24.3.124.

Therapeutic drug monitoring of vancomycin in a patient with Duchenne muscular dystrophy (DMD): A case report

Affiliations
  • 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul 03080, Korea. leejh413@snu.ac.kr

Abstract

Vancomycin is a widely used glycopeptide antibiotic that requires therapeutic drug monitoring (TDM) owing to its narrow therapeutic window. It is primarily eliminated by renal excretion; thus, estimating the renal function of a patient is vital in the TDM of vancomycin. In patients with Duchenne muscular dystrophy (DMD), it is difficult to estimate the glomerular filtration rate using the serum creatinine level owing to the pathophysiological nature of the disease. Here, we report a case of a patient in whom TDM of vancomycin was performed, and explore the appropriate methods for evaluating renal function in patients with DMD based on serum levels of creatinine and cystatin C.

Keyword

Vancomycin; Therapeutic drug monitoring; Renal function; Serum creatinine; Duchenne muscular dystrophy

MeSH Terms

Creatinine
Cystatin C
Drug Monitoring*
Glomerular Filtration Rate
Humans
Muscular Dystrophy, Duchenne*
Renal Elimination
Vancomycin*
Creatinine
Cystatin C
Vancomycin

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