Korean J Radiol.  2016 Feb;17(1):103-110. 10.3348/kjr.2016.17.1.103.

Quantitative Analysis of Disc Degeneration Using Axial T2 Mapping in a Percutaneous Annular Puncture Model in Rabbits

Affiliations
  • 1Department of Radiology, SMG-SNU Boramae Medical Center, Seoul 07061, Korea.
  • 2Department of Radiology, Seoul National University Bundang Hospital, Seongnam 13620, Korea. heungskang@gmail.com
  • 3Department of Radiology, Seoul National University Hospital, Seoul 03080, Korea.

Abstract


OBJECTIVE
To evaluate T2 relaxation time change using axial T2 mapping in a rabbit degenerated disc model and determine the most correlated variable with histologic score among T2 relaxation time, disc height index, and Pfirrmann grade.
MATERIALS AND METHODS
Degenerated disc model was made in 4 lumbar discs of 11 rabbits (n = 44) by percutaneous annular puncture with various severities of an injury. Lumbar spine lateral radiograph, MR T2 sagittal scan and MR axial T2 mapping were obtained at baseline and 2 weeks and 4 weeks after the injury in 7 rabbits and at baseline and 2 weeks, 4 weeks, and 6 weeks after the injury in 4 rabbits. Generalized estimating equations were used for a longitudinal analysis of changes in T2 relaxation time in degenerated disc model. T2 relaxation time, disc height index and Pfirrmann grade were correlated with the histologic scoring of disc degeneration using Spearman's rho test.
RESULTS
There was a significant difference in T2 relaxation time between uninjured and injured discs after annular puncture. Progressive decrease in T2 relaxation time was observed in injured discs throughout the study period. Lower T2 relaxation time was observed in the more severely injured discs. T2 relaxation time showed the strongest inverse correlation with the histologic score among the variables investigated (r = -0.811, p < 0.001).
CONCLUSION
T2 relaxation time measured with axial T2 mapping in degenerated discs is a potential method to assess disc degeneration.

Keyword

MRI; T2 mapping; Degeneration; Intervertebral disc; Rabbit

MeSH Terms

Animals
Disease Models, Animal
Intervertebral Disc/injuries/*pathology
Intervertebral Disc Degeneration/*pathology
Lumbar Vertebrae/*pathology
Magnetic Resonance Imaging/*methods
Male
Punctures
Rabbits
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