Korean J Crit Care Med.  2016 May;31(2):129-133. 10.4266/kjccm.2016.31.2.129.

Primary Invasive Intestinal Aspergillosis in a Non-Severely Immunocompromised Patient

  • 1Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dr99.park@samsung.com
  • 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Invasive aspergillosis (IA) is most commonly seen in patients with risk factors, such as cytotoxic chemotherapy, prolonged neutropenia, corticosteroids, transplantation and acquired immune deficiency syndrome. IA commonly occurs in the respiratory tract. Extrapulmonary aspergillosis is usually a part of a disseminated infection, and primary invasive intestinal aspergillosis is very rare. Herein, we report a case of an immunocompetent 53-year-old male who suffered recurrent septic shock in the intensive care unit (ICU) and was finally diagnosed as invasive intestinal aspergillosis without dissemination. IA is rarely considered for patients who do not have an immune disorder. Thus, when such cases do occur, the diagnosis is delayed and the clinical outcome is often poor. However, there is a growing literature reporting IA cases in patients without an immune disorder, mostly among ICU patients. Primary intestinal aspergillosis should be considered for critically ill patients, especially with severe disrupted gastrointestinal mucosal barrier.


critical illness; gastrointestinal disease; aspergillosis

MeSH Terms

Acquired Immunodeficiency Syndrome
Adrenal Cortex Hormones
Critical Illness
Drug Therapy
Gastrointestinal Diseases
Immune System Diseases
Immunocompromised Host*
Intensive Care Units
Middle Aged
Respiratory System
Risk Factors
Shock, Septic
Adrenal Cortex Hormones
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