J Bone Metab.  2016 Aug;23(3):129-134. 10.11005/jbm.2016.23.3.129.

Association between Homocysteine and Bone Mineral Density according to Age and Sex in Healthy Adults

• Kim JI
• Moon JH
• Chung HW
• Kong MH
• Kim HJ

• KMID: 2350808
• DOI: http://doi.org/10.11005/jbm.2016.23.3.129

Abstract

BACKGROUND
There are several studies about the relationship between serum homocysteine levels and bone mineral density (BMD), but the results are varied, and the studies are limited in Korea. In our study, the relationship between serum homocysteine levels and BMD by part according to age and sex is investigated.
METHODS
From March 2012 to July 2015, the 3,337 healthy adults who took a medical examination were recruited. Subjects filled in the self-recording type questionnaire and physical examination, blood test, BMD of lumbar spine and femur were measured. After sorting by aging (≤49 year old, 50-59 year old, ≥60 year old) and sex, the results were adjusted with age and body mass index (BMI) and the relationship between serum homocysteine levels and BMD by lumbar spine and femur was analyzed by multiple regression analysis.
RESULTS
As results of analysis, with the adjustment with age and BMI, all age groups of men had no significant relationship between log-converted serum homocysteine levels and BMD. In women aged under 50, there were significantly negative relationships at lumbar spine (β=-0.028, P=0.038), femur neck (β=-0.062, P=0.001), and total hip (β=-0.076, P<0.001), but there was no significant relationship in other age groups (50-59 year old and ≥60 year old).
CONCLUSIONS
As the serum homocysteine levels increased in women aged under 50, BMD of the lumbar spine and femur decreased, and correlations between homocysteine and BMD were different by sex and age.

Keyword

Bone density; Homocysteine; Osteoporosis

MeSH Terms

Adult*
Aging
Body Mass Index
Bone Density*
Female
Femur
Femur Neck
Hematologic Tests
Hip
Homocysteine*
Humans
Korea
Male
Osteoporosis
Physical Examination
Spine
Homocysteine

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