Korean J Gastroenterol.  2016 Aug;68(2):87-92. 10.4166/kjg.2016.68.2.87.

Rare Case of Primary Gastric Burkitt Lymphoma in a Child

• Kim SC
• Hwang JW
• Lee MK
• Hwang PH

• KMID: 2350085
• DOI: http://doi.org/10.4166/kjg.2016.68.2.87

Abstract

Primary gastric tumors are very rare in children. Burkitt lymphoma is a common type of non-Hodgkin's lymphoma, and gastric Burkitt lymphoma usually occurs in the aged. When involving the gastrointestinal tract, primary gastric Burkitt lymphoma is very rare in younger childhood. Many gastric lymphomas including mucosa-associated lymphoid tissue lymphoma are associated with Helicobacter pylori infection or acute bleeding symptom. We report a seven-year-old boy who presented with only some vomiting and postprandial pain. His upper gastrointestinal endoscopy and biopsy revealed a large primary Burkitt lymphoma with no acute bleeding and no evidence of H. pylori infection. After chemotherapy, he remains in remission.

Keyword

Burkitt lymphoma; Gastric cancer; Non-Hodgkin lymphoma

MeSH Terms

Biopsy
Burkitt Lymphoma*
Child*
Drug Therapy
Endoscopy, Gastrointestinal
Gastrointestinal Tract
Helicobacter pylori
Hemorrhage
Humans
Lymphoma
Lymphoma, B-Cell, Marginal Zone
Lymphoma, Non-Hodgkin
Male
Stomach Neoplasms
Vomiting

Figure

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  Fig. 1. Simple abdominal X-ray shows mass-like lesion in the epigastric and in the left infra-phrenic area.

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  Fig. 2. Contrast-enhanced coronal CT reveals diffuse thickening of the gastric wall with heterogeneous enhancement.

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  Fig. 3. Gastroscopic finding. A huge well-demarcated ulcerative lesion with neighboring mucosal elevation and irregular margin is seen at the cardia.

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  Fig. 4. Gastric tissue histology. (A) This slide shows lymphoid and monomorphic round cells is diffusely infiltrated within mucosa (H&E, ×400). The immunohistochemistry slides show the destructive infiltration of B-cell lineage. The tumor cells are positive for (B) CD20 (×400), (C) CD10 (×400), and (D) Bcl-6 protein (×400). (E) Total tumor cells are Ki-67 positive (×400).

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  Fig. 5. Fludeoxyglucose (FDG) PET/CT. Diffuse and nodular FDG uptake in the stomach, omentum, mesentery, and pelvic dependent peritoneum.

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  Fig. 6. Gastroscopic finding after three years. Normal appearance of gastric mucosa is seen at the same location (the previous lesion of cardia).

Reference

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