World J Mens Health.  2016 Aug;34(2):65-72. 10.5534/wjmh.2016.34.2.65.

Nonsurgical Interventions for Peyronie's Disease: Update as of 2016

Affiliations
  • 1The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. gjoice1@jhmi.edu

Abstract

Peyronie's disease (PD) is a debilitating condition of the penis that leads to significant pain, erectile dysfunction, and emotional distress in men. PD is likely underreported due to lack of knowledge of the disease and the absence of well-established available treatments. Surgical treatment can lead to sustained improvements, but is often associated with penile shortening and places the patient at risk for perioperative morbidity. Nonsurgical management has been studied for several years as an alternative to surgery for men with PD. Currently, much of the data on nonsurgical management is conflicting, with only one treatment that has been recently approved by the US Food and Drug Administration. Significant effort has been devoted to advancing non-surgical treatments for PD that can be implemented outside of the operating room. This review aims to describe the research behind current nonsurgical therapies for PD and to highlight the recent advances that have been made within the last three years.

Keyword

Erectile dysfunction; Injections, intralesional; Penile induration

MeSH Terms

Erectile Dysfunction
Humans
Injections, Intralesional
Male
Operating Rooms
Penile Induration*
Penis
United States Food and Drug Administration

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