Korean J Asthma Allergy Clin Immunol.  2009 Dec;29(4):289-292.

A Case of Diclofenac-induced Angioedema Requiring Emergency Tracheostomy

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed, which have an inflammation as well as an analgestic effects reducing effect. However, NSAIDs also have many potential adverse reactions, and NSAID- induced angioedema occurs infrequently. Angioedema is characterized by an acute-onset non-pitting edema of the skin, mucosa and subcutaneous tissue. With a particular predilection for the head and neck area including the face, lips, tongue and pharynx, angioedema may be fatal by causing acute upper airway obstruction. We report a case of diclofenac-induced angioedema, involving the soft palate, uvula, tongue and pharynx, complicated by impending upper airway obstruction requiring emergency tracheostomy. This is the first reported case, to our knowledge, of diclofenac- induced angioedema in Korea.

MeSH Terms

Airway Obstruction
Angioedema
Anti-Inflammatory Agents, Non-Steroidal
Diclofenac
Edema
Emergencies
Head
Inflammation
Korea
Mucous Membrane
Neck
Palate, Soft
Pharynx
Skin
Subcutaneous Tissue
Tongue
Tracheostomy
Uvula
Anti-Inflammatory Agents, Non-Steroidal
Diclofenac