J Pathol Transl Med.  2016 Jul;50(4):318-321. 10.4132/jptm.2015.10.17.

Gastric Mixed Adenoneuroendocrine Carcinoma with Squamous Differentiation: A Case Report

• Bae HI
• Lee C
• Jo YM
• Kwon O
• Yu W
• Kim MS
• Seo AN

• KMID: 2345558
• DOI: http://doi.org/10.4132/jptm.2015.10.17

Abstract

No abstract available.

Figure

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  Fig. 1. (A) A computed tomography scan demonstrating a large ulcerofungating hypodense mass in the anterior gastric wall (arrow) and enlargement of multiple perigastric lymph nodes (arrowhead). Macroscopic findings (B) and cross-section of gastric cancer (C). (D) Mapping of the gastric mixed adenoneuroendocrine carcinoma with trilineage histologic differentiation composed of adenocarcinoma (pink color), large cell neuroendocrine carcinoma, and squamous cell carcinoma (green color).

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  Fig. 2. Representative microscopic findings of mixed adenoneuroendocrine carcinoma with trilineage histologic differentiation. (A) Moderately differentiated adenocarcinoma admixed with large cell neuroendocrine carcinoma (NEC). (B) The NEC component demonstrates positive staining for chromogranin A, whereas the adenocarcinoma component shows negativity. (C) Squamous cell carcinoma (SqCC) component admixed with the NEC component, and (D) the NEC component presented positivity for chromogranin A, but not the SqCC component. (E) The cells with squamous cell differentiation are identified by expression of p63. (F) Metastasis of only the adenocarcinoma component to the gastric regional lymph nodes.

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  Fig. 3. Photomicrographs of immunohistochemistry (IHC) for c-erbB2 in mixed adenoneuroendocrine carcinoma with trilineage histologic differentiation. IHC for c-erbB2 shows strong positivity in the adenocarcinoma component (A), and in the metastatic regional lymph nodes (B), whereas IHC for c-erbB2 is negative in neuroendocrine carcinoma (C) and squamous cell carcinoma component (D).

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