Anesth Pain Med.  2016 Jul;11(3):249-254. 10.17085/apm.2016.11.3.249.

Evaluation of palonosetron for the prevention of pain on injection of LCT/MCT propofol: Randomized controlled comparison with lidocaine

• Yoo JH
• Kim YI
• Kim SI
• Lee SJ
• Han YM

• KMID: 2344926
• DOI: http://doi.org/10.17085/apm.2016.11.3.249

Abstract

BACKGROUND
Long-chain triglyceride/medium-chain triglyceride (LCT/MCT) propofol is less painful than standard long chain triglyceride (LCT) propofol; however, there is still a need to reduce severe pain. 5-Hydroxytryptamine type 3 (5-HT3) receptor antagonists have an analgesic effect during the injection of standard LCT propofol. This study compared the incidence of moderate-to-severe injection pain with LCT/MCT propofol using pretreatment with palonosetron versus pretreatment with saline or lidocaine.
METHODS
This prospective, randomized double-blind study divided 98 patients scheduled for general anesthesia into three groups: control (n = 33), palonosetron (n = 32), and lidocaine (n = 33) groups. An 18-gauge intravenous catheter was inserted into the peripheral vein at the dorsum of the hand. The patient's vein was occluded by a rubber tourniquet at mid-forearm, and we then administered 2 ml of the pretreatment drug. One minute after venous occlusion, we released the tourniquet and administered LCT/MCT propofol 2 mg/kg for 10-15 seconds. The degree of pain on propofol injection was evaluated using a 4-point scale.
RESULTS
The incidence of moderate-to-severe pain in the control, palonosetron, and lidocaine groups was 9.1, 15.6, and 12.1%, respectively. The incidence of overall pain was lower in the lidocaine group than in the control or palonosetron group.
CONCLUSIONS
Palonosetron and lidocaine pretreatment does not reduce moderate-to-severe pain on injection of 1% LCT/MCT propofol. Lidocaine pretreatment reduced the overall incidence of injection pain.

Keyword

Injections; Pain; Palonosetron; Propofol

MeSH Terms

Anesthesia, General
Catheters
Double-Blind Method
Hand
Humans
Incidence
Lidocaine*
Propofol*
Prospective Studies
Rubber
Serotonin
Tourniquets
Triglycerides
Veins
Lidocaine
Propofol
Rubber
Serotonin

Figure

• 

  Fig. 1 The incidences of overall pain and moderate-to-severe pain with propofol injection. The incidence of overall pain was lower in the lidocaine group compared with the control group (P = 0.028). The incidence of moderate-to-severe pain did not differ among the three groups (P = 0.693).

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