Korean Circ J.  2016 May;46(3):394-401. 10.4070/kcj.2016.46.3.394.

Obesity and Hypertension in Association with Diastolic Dysfunction Could Reduce Exercise Capacity

• Kim J
• Kim MG
• Kang S
• Kim BR
• Baek MY
• Park YM
• Shin MS

• KMID: 2344452
• DOI: http://doi.org/10.4070/kcj.2016.46.3.394

Abstract

BACKGROUND AND OBJECTIVES
Empirical evidence is lacking on the cumulative disease burden of obesity and hypertension and its impact on cardiac function and exercise capacity. The purpose of this study was to determine whether the presence of obesity and hypertension together was associated with cardiac dysfunction and exercise capacity.
SUBJECTS AND METHODS
Using a retrospective study design, medical records were reviewed for echocardiographic and treadmill exercise stress test data. Subjects were grouped according to four categories: normal control, obese, hypertensive, or obese and hypertensive.
RESULTS
Obese, hypertensive persons showed significantly lower Ea and E/A ratio and greater E/Ea ratio, deceleration time, left ventricular (LV) mass, and LV mass index compared to their counter parts (normal control, obese and/or hypertensive) (all p<0.05), after controlling for age and sex. After controlling for age and sex, significant differences in exercise capacity indices were found, with the obese group having shorter exercise time, lower metabolic equivalents, and lower maximal oxygen uptake than the normal control, hypertensive, or both groups (all p<0.05). The hypertensive or obese and hypertensive group had greater maximal blood pressure compared with the normal control group (all p<0.001). Obese and hypertensive persons were approximately three times more likely to have diastolic dysfunction (odd ratio=2.96, p=0.001), when compared to the reference group (normotensive, non-obese, or hypertensive only persons).
CONCLUSION
Diastolic dysfunction was associated with obesity and/or hypertension. The cumulative risk of obesity and hypertension and their impact on diastolic dysfunction which could be modifiable could reduce exercise capacity.

Keyword

Obesity; Hypertension; Echocardiography; Diastolic function; Exercise capacity

MeSH Terms

Blood Pressure
Deceleration
Echocardiography
Exercise Test
Humans
Hypertension*
Medical Records
Metabolic Equivalent
Obesity*
Oxygen
Retrospective Studies
Oxygen

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