Cancer Res Treat.  2016 Jul;48(3):942-947. 10.4143/crt.2015.362.

TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

Affiliations
  • 1Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea.
  • 2Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea. chorong24@gmail.com
  • 3Department of Internal Medicine, National Medical Center, Seoul, Korea.
  • 4Department of Otorhinolaryngology, Korea Cancer Center Hospital, Seoul, Korea.

Abstract

PURPOSE
A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer. This TERT promoter mutation is thought to be a prognostic molecular marker, because its association with tumor aggressiveness, persistence/recurrence, and disease-specific mortality in papillary thyroid carcinoma (PTC) has been reported. In this study, we attempted to determine whether the impact of the TERT promoter mutation on PTC persistence/recurrence is independent of clinicopathological parameters.
MATERIALS AND METHODS
Using propensity score matching, 39 patients with PTC persistence or recurrence were matched with 35 patients without persistence or recurrence, with a similar age, sex, tumor size, multifocality, bilaterality, extrathyroidal extension, and lymph node metastasis. The TERT promoter and the BRAF V600E mutations were identified from PTC samples.
RESULTS
The TERT promoter mutation was detected in 18% of PTC patients (13/74). No significant difference in the frequency of the TERT promoter mutation was observed between the persistence/recurrence group and the non-recurrence group.
CONCLUSION
These results suggest that the prognostic implications of the TERT promoter mutation are dependent on clinicopathological parameters.

Keyword

Papillary thyroid cancer; Telomerase; Thyroid neoplasms

MeSH Terms

Humans
Lymph Nodes
Mortality
Neoplasm Metastasis
Propensity Score
Recurrence
Telomerase
Thyroid Gland*
Thyroid Neoplasms*
Telomerase

Reference

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