J Korean Neuropsychiatr Assoc.  2013 Sep;52(5):301-310.

Neuroeconomics and Psychiatry : Application of Quantitative Methodology

• Lee S
• Park SC

Abstract

Neuroeconomics is an interdisciplinary field that seeks to explain human decision making using a combination of research methods from neuroscience, (behavioral) economics, and cognitive and social psychology. With recent advances in functional neuroimaging and computing power, neuroeconomics suggests the possibility of examining psychopathology using a quantitative model based on objective metrics. The purpose of this paper is to introduce the theory of neuroeconomics and to review the literature on its application to psychiatric research. First, the concept of utility function in economic decision theory can be used to explain depressive symptoms with regard to lack of interest in money. Second, differences in attitudes toward uncertainty and risk suggest that avolition and anhedonia can be expected to reduce the influence of uncertainty on decision making. Third, some parametrically varied values of delay discounting show the relation of discounted value to risk of addiction. Finally, economic game theory can provide a model including social factors to address psychiatric conditions ; thus, it provides a useful framework for the current diagnostic classification systems for consideration of interpersonal factors. We expect that conduct of more interdisciplinary research in neuroeconomics and psychiatry will clarify diagnosis and contribute to the description of psychiatric disorders.

Keyword

Neuroeconomics; Psychiatric disorder; Utility function; Risk aversion; Game theory

MeSH Terms

Anhedonia
Decision Making
Decision Theory
Depression
Functional Neuroimaging
Game Theory
Humans
Neurosciences
Psychology, Social
Psychopathology
Uncertainty

Figure

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  Fig. 1 Utility functions according to risk aversion.

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  Fig. 2 An example of dynamic game.

Reference

1. Camerer C, Loewenstein G, Prelec D. Neuroeconomics: how neuroscience can inform economics. J Econ Lit. 2005; 43:9–64.

2. Center for Neuroeconomics Study at Duke University. Available from http://neuroeconomics.duke.edu/research/research2.html.

3. Glimcher PW, Rustichini A. Neuroeconomics: the consilience of brain and decision. Science. 2004; 306:447–452.

4. Hasler G. Can the neuroeconomics revolution revolutionize psychiatry? Neurosci Biobehav Rev. 2012; 36:64–78.

5. Sharp C, Monterosso J, Montague PR. Neuroeconomics: a bridge for translational research. Biol Psychiatry. 2012; 72:87–92.

6. Hasler G. Can the neuroeconomics revolution revolutionize psychiatry? Neurosci Biobehav Rev. 2012; 36:64–78.

7. Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing and endophenotype strategy for bipolar disorders. Biol Psychiatry. 2006; 60:93–105.

8. Hasler G, Drevets WC, Manji HK, Charney DS. Discovering endophenotypes for major depression. Neuropsychopharmacology. 2004; 29:1765–1781.

9. Dayan P, Huys QJ. Serotonin in affective control. Annu Rev Neurosci. 2009; 32:95–126.

10. Hasler G, LaSalle VH, Ronquillo J, Tunison S, Cochran LW, Greenberg BD, et al. Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res. 2005; 135:121–132.

11. Hasler G, Luckenbaugh DA, Snow J, Meyers N, Waldeck T, Geraci M, et al. Reward processing after catecholamine depletion in unmedicated remitted subjects with major depressive disorder. Biol Psychiatry. 2009; 66:201–205.

12. Gotlib IH, Hamilton JP, Cooney RE, Singh MK, Henry ML, Joormann J. Neural processing of reward and loss in girls at risk for major depression. Arch Gen Psychiatry. 2010; 67:380–387.

13. Kahneman D, Tversky A. Prospect theory-analysis of decision under risk. Econom. 1979; 47:263–291.

14. Hastie R, Dawes RM. Rational Choice in an uncertain world: The psychology of judgment and decision making. 2nd ed. Thousnad Oaks, California: Sage Publications;2001.

15. Platt ML, Huettel SA. Risky business: the neuroeconomics of decision making under uncertainty. Nat Neurosci. 2008; 11:398–403.

16. Mohr PN, Biele G, Heekeren HR. Neural processing of risk. J Neurosci. 2010; 30:6613–6619.

17. Paulus MP, Rogalsky C, Simmons A, Feinstein JS, Stein MB. Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism. Neuroimage. 2003; 19:1439–1448.

18. Hartley CA, Phelps EA. Anxiety and decision-making. Biol Psychiatry. 2012; 72:113–118.

19. Ernst M. The usefulness of neuroeconomics for the study of depression across adolescence into adulthood. Biol Psychiatry. 2012; 72:84–86.

20. Ernst M, Pine DS, Hardin M. Triadic model of the neurobiology of motivated behavior in dolescence. Psychol Med. 2006; 36:299–312.

21. Lerner JS, Small DA, Loewenstein G. Heart strings and purse strings: carryover effects of emotions on economcis decisions. Psychol Sci. 2004; 15:337–341.

22. Cavanagh JF, Frank MJ, Allen JJB. Social stress reactivity alters reward and punishment learning. Soc Cogn Affect Neurosci. 2011; 6:311–320.

23. Arrow KJ. Rationality of self and others in an economic system. J Bus. 1986; 59:S385–S399.

24. Gottdiener WH, Murawski P, Kucharski LT. Using the delay discounting task to test for failures in ego control in substance abusers: a meta-analysis. Psychoanal Psychol. 2008; 25:533–549.

25. Reynolds B. A review of delay-discounting research with humans: relations to drug use and gambling. Behav Pharmacol. 2006; 17:651–667.

26. McClure SM, Laibson DI, Loewenstein G, Cohen JD. Separate neural systems value immediate and delayed monetary rewards. Science. 2004; 306:503–507.

27. Bickel WK, Miller ML, Yi R, Kowal BP, Lindquist DM, Pitcock JA. Behavioral and neuroeconomics of drug addiction: competing neural systems and temporal discounting processes. Drug Alcohol Depend. 2007; 90:S85–S91.

28. Nash J. Equilibrium points in n-person games. Proc Natl Acad Sci U S A. 1950; 36:48–49.

29. Fairburn CG, Norman PA, Welch SL, O'Connor ME, Doll HA, Peveler RC. A prospective study of outcome in bulimia nervosa and the long-term effects of three psychological treatments. Arch Gen Psychiatry. 1995; 52:304–312.

30. Fehr E, Schmidt K. A theory of fairness, competition and cooperations. Quart J Econ. 1999; 114:817–868.

31. Camerer CF, Fehr E. Measuring social norms and preferences using experimental games: a guide for social scientists. In : Henrich J, Boyd R, Bowles S, Camerer C, Fehr E, Gintis H, editors. Foundations of human sociality. New York: Oxford University Press;2004.

32. Tricomi E, Rangel A, Camerer CF, O'Doherty JP. Neual evidence for inequality-averse social preferences. Nature. 2010; 463:1089–1091.

33. King-Casas B, Chiu PH. Understanding interpersonal function in psychiatric illness through multiplayer economic games. Biol Psychiatry. 2012; 72:119–125.

34. King-Casas B, Sharp C, Lomax-Bream L, Lohrenz T, Fonagy P, Montague PR. The rupture and repair of cooperation in borderline personality disorder. Science. 2008; 321:806–810.

35. Rilling JK, Glenn AL, Jairam MR, Pagnoni G, Goldsmith DR, Elfenbein HA, et al. Neural correlates of social cooperation and non-cooperation as a function of psychopathy. Biol Psychiatry. 2007; 61:1260–1271.

36. Sripada CS, Angstadt M, Banks S, Nathan PJ, Liberzon I, Phan KL. Functional neuroimaging of mentalizing during the trust game in social anxiety disorder. Neuroreport. 2009; 20:984–989.

37. Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006; 7:268–277.

38. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington DC: American Psychiatric Association;2000.

39. Yoshida W, Dziobek I, Kliemann D, Heekeren HR, Friston KJ, Dolan RJ. Cooperation and heterogeneity of the autistic mind. J Neurosci. 2010; 30:8815–8818.

40. Yoshida W, Dolan RJ, Friston KJ. Game theory of mind. PLoS Comput Biol. 2008; 4:e1000254.

41. Declerck CH, Boone C, Emonds G. When do people cooperate? The neuroeconomics of prosocial decision making. Brain and Cognition. 2013; 81:95–117.

42. Cho SC. The Concept of Consilience in the Field of Psychiatry. J Korean Neuropsychiatr Assoc. 2012; 51:349–358.