J Korean Neurol Assoc.  2006 Aug;24(4):389-391.

A Case of Glycyrrhizin (Licorice)-induced Hypokalemic Myopathy

Affiliations
  • 1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea. pks1126@chol.com
  • 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Glycyrrhizin, the main ingredient of licorice, may evoke severe hypokalemia and muscle paralysis by its mineralocorticoid effects. We present a 78-year-old man who developed subacute flaccid quadriparesis with a high creatine kinase (CK) level, hypokalemia, metabolic alkalosis, and low plasma renin activity after ingesting licorice daily for two years. A muscle biopsy revealed vacuolar degeneration of myofibers. This case suggests that glycyrrhizin (licorice)-induced hypokalemic myopathy must be included in the differential diagnosis of a patient with generalized muscle weakness and hypokalemia.

Keyword

Licorice; Glycyrrhizin; Hypokalemic myopathy; Vacuolar degeneration

MeSH Terms

Aged
Alkalosis
Biopsy
Creatine Kinase
Diagnosis, Differential
Glycyrrhiza
Glycyrrhizic Acid*
Humans
Hypokalemia
Mineralocorticoids
Muscle Weakness
Muscular Diseases*
Paralysis
Plasma
Quadriplegia
Renin
Creatine Kinase
Glycyrrhizic Acid
Mineralocorticoids
Renin
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