J Korean Neuropsychiatr Assoc.  2010 Mar;49(2):256-259.

A Case of Schizophrenia with Periventricular Leukomalacia on Magnetic Resonance Imaging

Affiliations
  • 1Department of Psychiatry, Chosun University College of Medicine, Gwangju, Korea. moonin151@chosun.ac.kr

Abstract

Schizophrenia was once known as a functional psychosis, a disorder with no structural basis. However, nowadays research has identified and confirmed many structural abnormalities in schizophrenia. One prominent such feature is the combination of ventricular enlargement and decreased cerebral volume. Periventricular leukomalacia causes cerebral palsy, cognitive impairment, visual impairment, and seizures. Recent studies reveal that periventricular leukomalacia causes ventricular enlargement and many brain circuit disruptions. Ventricular enlargement caused by periventricular leukomalacia is the most common pathological marker of schizophrenia. In this study, we report a case with periventricular leukomalacia on MRI findings in a 28-year-old schizophrenia patient. This patient showed auditory hallucinations and somatic delusions. We highlight the structural abnormalities, especially periventricular leukomalacia, in this case of schizophrenia.

Keyword

Periventricular leukomalacia; Magnetic resonance imaging; Schizophrenia

MeSH Terms

Adult
Brain
Cerebral Palsy
Delusions
Hallucinations
Humans
Infant, Newborn
Leukomalacia, Periventricular
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Magnetics
Magnets
Psychotic Disorders
Schizophrenia
Seizures
Vision Disorders
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