J Korean Neuropsychiatr Assoc.  2004 Jan;43(1):18-22.

Genetic Polymorphism of Endothelial Nitric Oxide Synthase in Korean Schizophrenic Patients

Affiliations
  • 1Department of Psychiatry, College of Medicine, Chonbuk National University, Chonju, Korea. cjcsk@moak.chonbuk.ac.kr
  • 2Institute for Medical Science, College of Medicine, Chonbuk National University, Chonju, Korea.
  • 3Department of Laboratory Medicine, College of Medicine, Chonbuk National University, Chonju, Korea.

Abstract


OBJECTIVES
Although genotype of endothelial nitric oxide synthase has been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the nature of endothelial nitric oxide synthase in Korean schizophrenic patients, and compare it with healthy control group in terms of distribution of e genotype and allele frequency of endothelial nitric oxide synthase.
METHODS
Using polymerase chain reaction and amplified refractory mutation system, endothelial nitric oxide synthase genotypes were identified in 77 schizophrenics and 121 healthy controls.
RESULTS
1) When genotypes of endothelial nitric oxide synthase were classified as a/a, a/b, b/b, there was no statistical difference in genotypes between the two groups. 2) In terms of allele frequency, there was also no statistical difference between the two groups.
CONCLUSION
These results suggest that endothelial nitric oxide synthase gene seem to be unrelated to the pathogenesis of schizophrenia in Korean population.

Keyword

Schizophrenia; Endothelial Nitric oxide synthase; Genotype; Polymorphism
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