J Korean Neuropsychiatr Assoc.  2002 Sep;41(5):796-804.

Neurogenesis and Psychiatry: Focusing on Mood Disorders

  • 1Department of Neuropsychiatry, School of Medicine, Kwandong University, Myongji Hospital, Koyang, Korea.
  • 2Department of Neuropsychiatry, School of Medicine and The Mental Health Research Institute, Hanyang University, Seoul, Korea.


Up to now, the adult brain has been considered largely refractory to regeneration and new neuronal birth(neurogenesis). However, recent studies have clearly revealed that the adult hippocampus, specifically the dentate gyrus, continues to give rise to new neurons throughout life in all mammalian species, including humans. The continual addition of immature neurons could allow restructuring of this area according to the current environment, thus providing important neural plasticity. On the other hand, these ongoing structural changes might render the dentate gyrus particularly sensitive to environmental perturbations that may impair hippocampal structure and function. Numerous studies have demonstrated that the proliferation, differentiation, and survival of new hippocampal neurons can be enhanced or diminished by hormones, biochemicals, drugs, and experiences. This review discusses the current state of knowledge regarding adult brain neurogenesis and the role of neurogenesis in mood disorder.


Hippocampus; Dentate gyrus; Neurogenesis; Mood disorder
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