J Korean Neuropsychiatr Assoc.  1999 Sep;38(5):1186-1194.

Obsessive-compulsive Disorder in a Patient with 47,XXX, Triple X Syndrome

Affiliations
  • 1National Bukog Mental Hospital, Bukog, Korea.

Abstract

Triple X syndrome is a relatively rare sex chromosomal anomaly, and its association with psychopathology is not well understood. The authors report one case of obsessive-compulsive disorder(OCD)with karyotype-confirmed triple X syndrome, 47,XXX. She had incomplete sexual development, seconddary amenorrhea and multiple obsessive-compulsive symptoms. Magnetic resonance imaging of the brain revealed left occipital white matter hyperintensity lesion. The patient's multiple obsessive-compulsive symptoms were responded partially with fluoxetine and adjunctive buspirone treatment, however, her overall psychological functions were much improved. With the literature reviews, the authors suggest the possibility that a certain type of sex chromosome aneuploidy might be susceptible to obsessive-compulsive spectrum disorders(OCSDs)or OCD.

Keyword

Triple X syndrome; Obsessive-compulsive disorder; Obsessive-compulsive spectrum disorder

MeSH Terms

Amenorrhea
Aneuploidy
Brain
Buspirone
Female
Fluoxetine
Humans
Magnetic Resonance Imaging
Obsessive-Compulsive Disorder*
Psychopathology
Sex Chromosomes
Sexual Development
Buspirone
Fluoxetine
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