J Korean Ophthalmol Soc.  2015 Mar;56(3):371-378. 10.3341/jkos.2015.56.3.371.

Measurement of Deep Optic Nerve Complex Structures with Two Spectral Domain Optical Coherence Tomography Instruments

• Yu S
• Lee KW
• Lee TY

• KMID: 2339043
• DOI: http://doi.org/10.3341/jkos.2015.56.3.371

Abstract

PURPOSE
To assess the usefulness of two spectral domain optical coherence tomography (SD-OCT) instruments (Cirrus(R), Spectralis(R)) for evaluating optic nerve head and peripapillary structures.
METHODS
Images of optic nerve complex were obtained from 136 eyes of 136 patients using enhanced depth imaging technique of 2 SD-OCT instruments. Optic nerve head and peripapillary structures were investigated for their visibility and morphological features in total eyes and glaucomatous eyes. Effect factors for laminar thickness measurement were evaluated and the reproducibility of the lamina cribrosa thickness measured by the 2 OCT instruments was analyzed.
RESULTS
Lamina cribrosa thickness was better identified using Spectralis(R) OCT in total and glaucomatous eyes. Short posterior ciliary artery (in total eyes) and peripapillary choroid (in total and glaucomatous eyes) were also better identified using Spectralis(R) OCT (p < 0.001). A cup-disc ratio < or = 0.6 was the significant effect factor for laminar thickness measurement (p < 0.05). Interobserver reproducibility was excellent using both OCT instruments. Intraobserver reproducibility was excellent using Spectralis(R) OCT and moderate using Cirrus(R) OCT.
CONCLUSIONS
Spectralis(R) OCT was better for visualizing optic nerve head and peripapillary structures and showed better reproducibility than Cirrus(R) OCT. Thus, the Spectralis(R) may be helpful for detecting and understanding features of the optic nerve complex.

Keyword

Glaucoma; Lamina cribrosa; Peripapillary structure; Reproducibility; Spectral domain optical coherence tomography

MeSH Terms

Choroid
Ciliary Arteries
Glaucoma
Humans
Optic Disk
Optic Nerve*
Tomography, Optical Coherence*

Figure

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  Figure 1. Bland-Altman plot for lamina cribrosa thickness. Mean difference is 18.61 μm. The 95% limits of agreement for laminal thickness measurements are -40.90 to 80.14 μm.

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  Figure 2. Optic nerve head complex of cross-sectional images revealed using Cirrus® optical coherence tomography (OCT) (A), Spectralis® OCT (B). Black arrow heads in (A) and (B) denote suspected lamina cribrosa. Lamina cribrosa thickness was 230.77 μm measured by Cirrus® OCT (A) and 297.69 μm measured by Spectralis® OCT (B). Lamina cribrosa pores of various shapes and sizes well identified. Posterior border of lamina cribrosa is relatively less identified in (A). Central retinal vessel trunk (white arrow) passing through the lamina cribrosa identified. Short posterior ciliary artery (black arrow) are shown in the sclera draining into the choroid.

Reference

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