J Korean Ophthalmol Soc.  2014 Jun;55(6):868-876.

Choroidal Thickness in Primary Open-Angle Glaucoma Using Spectral-Domain Optical Coherence Tomography

• Kim JW
• Rhew JY
• Choi KR

Abstract

PURPOSE
To evaluate the choroidal thickness in patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) using spectral-domain optical coherence tomography (SD-OCT), and to explore the relationship between the choroidal thickness and glaucoma.
METHODS
A retrospective analysis was performed on patients who had been diagnosed with POAG or NTG at Ewha Womans University, Mokdong Hospital. SD-OCT scans were obtained to estimate retinal nerve fiber layer (RNFL) thickness, macular thickness, and subfoveal and peripapillary choroidal thickness in groups of POAG patients, NTG patients, and normal controls.
RESULTS
A total of 21 patients with POAG, 53 patients with NTG, and 42 normal subjects were enrolled in this study. RNFL thickness and macular thickness were significantly thinner in the POAG and NTG groups compared to the normal subjects. In contrast, there were no significant differences in subfoveal and peripapillary choroidal thickness among the 3 groups. There was no significant correlations between the peripapillary choroidal thickness and retinal nerve fiber layer thickness.
CONCLUSIONS
Choroidal thickness does not seem to differ between glaucoma patients and normal subjects, and there were no significant correlations between the choroidal thickness and glaucomatous optic neuropathy.

Keyword

Choroidal thickness; Spectral-domain optical coherence tomography (SD-OCT)

MeSH Terms

Choroid*
Female
Glaucoma
Glaucoma, Open-Angle*
Humans
Low Tension Glaucoma
Nerve Fibers
Optic Nerve Diseases
Retinaldehyde
Retrospective Studies
Tomography, Optical Coherence*
Retinaldehyde

Figure

• 

  Figure 1. Images from spectral-domain optical coherence tomography (SD-OCT) with enhanced-depth imaging (EDI). (A) Image from subfoveal SD-OCT scan. White line: line of measurements of the subfoveal choroidal thickness. (B) Image from 360-degree peripapillary SD-OCT scan. Examples of image depicting choroidal thickness and demonstrating manual delineation of choroidal vasculature lying between the outer border of the retinal pigment epithelium and the posterior choroidal vessels (white arrow with white dotted line, 0°: temporal, 45°: superotemporal, 90°: superior, 135°: superonasal, 180°: nasal, 225°: inferonasal, 270°: in-ferior, 315°: inferotemporal).

• 

  Figure 2. Graph of choroidal thickness in nor-mal subjects and NTG, POAG patients. Subfoveal and peripapillary choroidal thickness did not change significantly between normal subjects and NTG, POAG patients. NTG = normal tension glaucoma; POAG = primary open angle glaucoma.

Reference

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