J Korean Ophthalmol Soc.  2014 Apr;55(4):611-615.

A Case of Primary Signet Ring Cell Carcinoma of the Lower Eyelid

• Shin SA
• Kim SD
• Yun KJ

Abstract

PURPOSE
To report a rare case of a painless mass on the lower lid, histologically diagnosed as primary signet ring cell carcinoma of the eyelid.
CASE SUMMARY
A 74-year-old male presented with a painless mass on the right lower lid which had developed seven months prior to presentation. Incisional biopsy of the mass and attached lower lid skin was performed, revealing signet ring cell carcinoma. A systemic evaluation, including whole body positron emission tomography-computed tomography (PET-CT), chest CT, abdomen and pelvis CT, gastrointestinal endoscopy, and colonoscopy, revealed no other abnormal lesions. Therefore, the eyelid lesion was considered primary signet ring cell carcinoma of the skin and was treated with radiotherapy of 6600 cGy in 33 fractions over 7 weeks.
CONCLUSIONS
Herein, the authors report a rare case of primary signet ring cell carcinoma of the eyelid with no evidence of tumor recurrence or metastasis for 5 years after radiotherapy.

Keyword

Eyelid; Primary signet ring cell carcinoma

MeSH Terms

Abdomen
Aged
Biopsy
Carcinoma, Signet Ring Cell*
Colonoscopy
Electrons
Endoscopy, Gastrointestinal
Eyelids*
Humans
Male
Neoplasm Metastasis
Pelvis
Radiotherapy
Recurrence
Skin
Tomography, X-Ray Computed

Figure

• 

  Figure 1. Clinical photograph of the painless mass (black arrow) of the right lower eyelid.

• 

  Figure 2. Coronal (A) and axial (B) images of orbital computed tomography scan showing a mass in the right inferolateral orbit and diffuse soft tissue thickening with well enhancement in the right lacrimal fossa and preseptal area.

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  Figure 3. (A, B) Histopathology reveals the tumor cells have ec-centric nuclei and some of the tumor cells show signet ring-like appearance (black arrow) in the fibrosclerotic background (A: H&E, ×400) and in the skeletal muscle fibers (B: H&E, ×200).(C) The tumor cells show positive staining for cytokeratin (×200).

• 

  Figure 4. Orbital magnetic resonance imaging (MRI) showing no evidence of recurrence 5 years after radiotherapy. Post contrast T1-weighted axial (A) and coronal (B) views.

Reference

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