J Korean Ophthalmol Soc.  2012 Nov;53(11):1685-1688.

A Case of Primary Eyelid Peripheral T-Cell Lymphoma, Not Otherwise Specified

• Noh SJ
• Kie JH
• Kim HY

Abstract

PURPOSE
To report a case of primary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), of the eyelid.
METHODS
A 48-year-old healthy male patient presented with a mass on the upper lid of 2 months in duration. The lesion was reddish, well-demarcated, oval shaped, and measured approximately 8 x 4 mm. The mass did not respond to incisional drainage and intra-lesional triamcinolone. An excisional biopsy for diagnosis was performed.
RESULTS
On microscopic examination, a localized dense lymphocytic infiltration was observed in the subepithelial area, and cytologic atypia was observed under high power. On immunohistochemical examination, tumor cells were positive for CD3 but negative for CD20, CD30, CD56, k-light chain immunoglobulin, lambda-light chain immunoglobulin, and increased Ki-67 activity was noted. A histopathological diagnosis of PTCL-NOS was made.
CONCLUSIONS
PTCL-NOS, which rarely occurs on the eyelids, commonly accompanies generalized lymphadenopathy and "B symptoms" such as fever and weight loss. Herein, the authors report a case of PTCL-NOS of the eyelid presenting as a rapidly growing solid mass in an otherwise healthy patient.

Keyword

Eyelid tumor; Peripheral T-cell lymphoma; not otherwise specified

MeSH Terms

Biopsy
Drainage
Eyelids
Fever
Humans
Immunoglobulins
Lymphatic Diseases
Lymphoma, T-Cell, Peripheral
Male
Middle Aged
Triamcinolone
Weight Loss
Immunoglobulins
Triamcinolone

Figure

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  Figure 1 Preoperative appearance shows a reddish, well-demarcated, oval shaped mass in the right upper eyelid.

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  Figure 2 On microscopic examination, a localized dense lymphocytic infiltration is seen in the subepithelial area (A: H&E, ×40), and cytologic atypia is seen on high power (B: H&E, ×400). On immunohistochemical stain, these atypical lymphocytes show diffuse strong immunoreactivity for CD3 along the cytoplasmic membrane (C) with increased Ki-67 activity (D), which is consistent with peripheral T-cell lymphoma, not otherwise specified.

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