J Korean Ophthalmol Soc.  2011 Nov;52(11):1286-1295.

Use of Spectral-Domain Optical Coherence Tomography to Analyze Macular Thickness According to Refractive Error

Affiliations
  • 1Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. yhohn@schmc.ac.kr

Abstract

PURPOSE
To investigate the correlation of macular retinal thickness and refractive error using spectral-domain optical coherence tomography (SD-OCT).
METHODS
A total of 120 eyes with no posterior abnormalities were enrolled in the present study. Subjects were divided into 3 groups based on their spherical equivalent. Visual acuity, refraction, slit lamp examination, tonometry and fundus examination were performed. Retinal thickness between the RPE and IS/OS junction was measured at the fovea, 1 mm (inner ring) and 2 mm (outer ring) superiorly, inferiorly, nasally and temporally using SD-OCT. Overall average thickness, average foveal thickness, and the inner and outer ring macular thickness were measured.
RESULTS
The average foveal thickness was significantly greater in the high myopic eyes than in the low to moderate myopic and emmetropic eyes (p = 0.001). However, the RPE-IS/OS junction thickness of the foveola and the outer macular thickness were significantly lower (p = 0.001, p = 0.002) in the high myopic eyes. There was a weak, but significant negative correlation between refractive error and average foveal thickness (r = -0.38, p = 0.001). A positive correlation was found between refractive error and the RPE-IS/OS junction thickness (r = 0.40, p = 0.001).
CONCLUSIONS
Macular retinal thickness is related to refractive error in normal subjects. Effects of eyeball elongation are more apparent in high myopic eyes than in low to moderate myopic eyes. A significant decline in the RPE-IS/OS junction thickness suggests the photoreceptor outer segments in the foveola are damaged in high myopic eyes.

Keyword

Macula; Macular thickness; Myopia; Refractive error; Spectral-domain optical coherence tomography

MeSH Terms

Eye
Manometry
Myopia
Refractive Errors
Retinaldehyde
Tomography, Optical Coherence
Visual Acuity
Retinaldehyde

Figure

  • Figure 1. Intraretinal measurements in Cirrus HD-OCT. Retinal thickness between RPE and IS/OS junction was measured at the fovea, 1.0 mm superiorly, 1.0 mm inferiorly, 1.0 mm nasally, 1.0 mm temporally, 2.0 mm superiorly, 2.0 mm inferiorly, 2.0 mm nasally and 2.0 mm temporally (Blue bar in figure 1A), by manually using the scale supplied with the software (Black arrow in figure 1B). Note that measurements in 1.0 mm superiorly, inferiorly, nasally and temporally represent inner circle and measurements in 2.0 mm superiorly, inferiorly, nasally and temporally represent outer circle, similarly.

  • Figure 2. ETDRS subfields within standard 1, 3 and 6 mm diameter concentric circles on the right used for reporting retinal thickness. F = fovea; SI = superior Inner; NI = nasal inner; II = inferior inner; TI = temporal inner; SO = superior outer; NO = nasal outer; IO = inferior outer; TO = temporal outer.

  • Figure 3. Scatterplots show the relationship between spherical equivalent and macular measurements. As myopia became more severe, average foveal thickness (B) increased. In contrast, thickness between RPE-IS/OS junction (A), average outer thickness (C) and total macular volume (D) decreased as myopia became more severe.


Reference

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