J Korean Ophthalmol Soc.  2010 Aug;51(8):1071-1076.

Intravitreal Triamcinolone Versus Bevacizumab for Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion

• Kim H
• Moon S
• Kang J
• Yoon H

Abstract

PURPOSE
To compare clinical outcomes after intravitreal injection of triamcinolone acetonide or bevacizumab for the treatment of macular edema secondary to branch retinal vein occlusion.
METHODS
Sixty-six patients received an intravitreal injection of either triamcinolone acetonide or bevacizumab. Patients were retrospectively reviewed. Thirty-three out of 66 patients were treated with an intravitreal injection of triamcinolone acetonide, while the other 33 patients received a bevacizumab injection. All patients underwent a visual acuity test, optical coherence tomography imaging and ophthalmoscopic examination throughout the follow-up.
RESULTS
In the triamcinolone group, central macular thickness (CMT) decreased from 496.69 +/- 153.01 micrometer at baseline to 313.06 +/- 150.14 micrometer at the six-month follow-up visit, while in the bevacizumab group, CMT decreased from 441.30 +/- 185.79 micrometer to 295.67 +/- 188.80 micrometer (p<0.05). In the triamcinolone group, best-corrected visual acuity (BCVA) improved from logMAR 0.92 +/- 0.70 at baseline to logMAR 0.53 +/- 0.43 at the six-month follow-up visit, and in the bevacizumab group, BCVA improved from logMAR 0.74 +/- 0.47 to logMAR 0.34 +/- 0.33 (p<0.05).
CONCLUSIONS
The therapeutic effects of intravitreal triamcinolone acetonide showed no significant differences compared with those of intravitreal bevacizumab with regard to anatomical and functional outcomes.

Keyword

Bevacizumab; Branch retinal vein occlusion; Macular edema; Triamcinolone

MeSH Terms

Antibodies, Monoclonal, Humanized
Follow-Up Studies
Humans
Intravitreal Injections
Macular Edema
Retinal Vein
Retinal Vein Occlusion
Retinaldehyde
Retrospective Studies
Tomography, Optical Coherence
Triamcinolone
Triamcinolone Acetonide
Visual Acuity
Bevacizumab
Antibodies, Monoclonal, Humanized
Retinaldehyde
Triamcinolone
Triamcinolone Acetonide

Figure

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  Figure 1. The changes of mean visual acuity (logMAR) of triamcinolone group and bevacizumab group in patients with macular edema associated with branch retinal vein occlusion.

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  Figure 2. The changes of central macular thickness of triamcinolone group and bevacizumab group in patients with macular edema associated with branch retinal vein occlusion.

Reference

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