J Korean Ophthalmol Soc.  2010 Mar;51(3):393-400.

Comparison of Primary Vascular Dysregulation in Normal Tension Glaucoma and Primary Open Angle Glaucoma

• Suh W
• Park SC
• Kee CW

Abstract

PURPOSE
To evaluate the clinical symptoms or signs of primary vascular dysregulation (PVD) in patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG).
METHODS
From June 2008 to June 2009, we administered questionnaires to patients with glaucoma. The questionnaire was composed of 11 items, and the questionnaire results were compared between patients with NTG and POAG. NTG patients were subdivided by age(criterion: 55 years) and perimetric mean deviation (criterion: -6dB).
RESULTS
We detected a significant increase in hypotension (p=0.036) in NTG patients (n=133), compared to POAG patients (n=68). Migraines and emotional stress were more frequent in younger patients (<55 years) with NTG (46%, 71%, p=0.027) than in older patients (>55 years) with NTG (27.5%, 42.9%, p=0001). The frequency of drug sensitivity and systemic vasospasm is higher in older patients with NTG (28.6%, 17.4%) than younger patients with NTG (12.9%, 4.9%) but the rate of systemic vasospasm is much higher in younger patients, compared to the prevalence in the general Korean population. In patients with moderate and advanced NTG, hypotension is highly prevalent (p=0.018).
CONCLUSIONS
Hypotension is a greater risk factor for NTG than for POAG. Indeed, vascular factors may be correlated with NTG, especially in younger patients with moderate, advanced visual field defects.

Keyword

Normal tension glaucoma; Primary open angle glaucoma; Primary vascular dysregulation

MeSH Terms

Glaucoma
Glaucoma, Open-Angle
Humans
Hypotension
Low Tension Glaucoma
Migraine Disorders
Prevalence
Surveys and Questionnaires
Risk Factors
Stress, Psychological
Visual Fields

Figure

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  Figure 1. Questionnaire about primary vascular dysregulation

Reference

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