J Korean Ophthalmol Soc.  2007 Nov;48(11):1487-1493.

Fluorescein Angiographic Features in Central Retinal Vein Occlusion With and Without Optic Nerve Head Swelling

• Kim YH
• Kim SK

Abstract

PURPOSE: To investigate the characteristics of fluorescein angiograms (FAG) of the optic nerve head and retina according to the presence of optic nerve head swelling (ONHS) in central retinal vein occlusion (CRVO).
METHODS
The records of 69 eyes were reviewed, confirmed with the diagnosis of CRVO, and compared for several features according to the presence of ONHS. The best-corrected visual acuities and intraocular pressures were recorded and patterns of retinal hemorrhage were described. The presence of fluorescein filling defects of the optic disc, time till fluorescein started to fill at the optic disc, arteriovenous transit time, and nonperfused areas were assessed using FAG.
RESULTS
Forty-one patients without ONHS (group 1) and 28 patients with ONHS (group 2) were included. The mean ages for groups 1 and 2 were 61.4 and 56.9 years, respectively, and there was no significant difference the mean ages between the groups. The fluorescein filling defect of the optic disc was seen more often in group 1 (n=13) than in group 2 (n=2). Marginal irregularity of the foveal avascular zone due to perifoveal capillary drop out was seen significantly more often in group 1 (n=12) than in group 2 (n=2).
CONCLUSIONS
Fluorescein filling defects of the optic disc and perifoveal capillary drop out were more frequently seen in CRVO patients without ONHS. However, longitudinal studies are needed to confirm the prognostic value of ONHS and the correlation of filling defects with progressive optic neuropathy in CRVO.

Keyword

Central retinal vein occlusion; Fluorescein filling defect; Optic nerve head swelling

MeSH Terms

Capillaries
Diagnosis
Fluorescein*
Humans
Intraocular Pressure
Optic Disk*
Optic Nerve Diseases
Optic Nerve*
Retina
Retinal Hemorrhage
Retinal Vein*
Visual Acuity
Fluorescein

Figure

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  Figure 1. (A, D) Fundus photographs of central retinal vein occlusion without optic nerve head swelling. (B, C) Fluorescein angiograms show intact fluorescein filling of the optic disc. (E, F) Fluoresecin angiograms show persistent hypofluorescent area of the optic disc due to fluorescein filling defect.

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  Figure 2. (A, D) Fundus photographs of central retinal vein occlusion with optic nerve head swelling. (B, C) Fluorescein angiograms show intact fluorescein filling of the optic disc. (E, F) Fluorescein angiograms show persistent hypofluorescent area of the optic disc due to fluorescein filling defect.

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  Figure 3. Fluorescein angiogram shows the irregular margin of central foveal avascular zone due to breaks in the perifoveal capillary arcade.

Reference

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