J Korean Ophthalmol Soc.  2004 Nov;45(11):1885-1892.

Optic Nerve Head Analysis Obtained by Optical Coherence Tomography for the Diagnosis of Glaucoma in Koreans

• Sim JO
• Park CK

Abstract

PURPOSE
To find the optimal parameter of the optic nerve head (ONH) analysis using Optical Coherence Tomography (OCT) and to form a diagnostic classification for the detection of glaucoma in Koreans. METHODS: The subjects of this study were 799 eyes of 400 patients at Kangnam St. Mary's Hospital from June 2003 to March 2004. Complete ophthalmic examinations containing the visual field test and OCT ONH analysis (StratusOCT, software ver. 3.0, Carl Zeiss Meditec, Inc, Dublin, CA, USA) were performed and the results were analyzed in the normal, glaucoma suspect and glaucoma groups. RESULTS: In the 799 eyes, there were 378 glaucomatous eyes. There was a statistically significant difference between glaucoma and non-glaucoma patients in all parameters of OCT ONH analysis except for the disc area. The horizontal integrated rim area (HIRA) was most significantly correlated with the visual field indices (MD and CPSD) and was the most useful parameter in glaucoma detection. Based on age and HIRA, the new discriminant formula = -1.858 - 0.028 x Age + 2.518 x HIRA was obtained and its accuracy, sensitivity and specificity were 72.8%, 71.5% and 73.8% respectively. CONCLUSIONS: HIRA was the most useful parameter in the detection of glaucoma. The new discriminant formula from OCT ONH analysis is expected to be useful in the diagnosis and follow-up of glaucoma in Koreans.

Keyword

Glaucoma; Optic nerve head analysis; Optical coherence tomography

MeSH Terms

Classification
Diagnosis*
Follow-Up Studies
Glaucoma*
Humans
Optic Disk*
Optic Nerve*
Sensitivity and Specificity
Tomography, Optical Coherence*
Visual Field Tests
Visual Fields