J Korean Ophthalmol Soc.  1999 Jan;40(1):146-153.

The Effect of Intravitreal Injection of Retinoic Acid on Experimentally Induced Proliferative Vitreoretinopathy using Human Retinal Prgment Epithelium in Rabbits

• Kim MS
• Yang HN

Abstract

The retinoic acid have been demonstrated to modulate the growth and differentiation of several cell types including retinal pigment epithelium.We evaluated the effect of intravitreal infection of retinoic acid on experimentally induced PVR using human retinal pigment epithelium in the rabbit. 35 eyes of rabbit were induced PVR by injecting of human retinal pigment epithelial cells and were divided into three groups; Control group, group 1(retinoic acid 0.05mg/0.1ml DMSO was injected) and group 2(retinoic acid 0.1mg/0.1ml DMSO was injected). The stages of PVR were observed on days 3, 7, 14 and 28. The mean PVR stage progressed in all three groups. The PVR stage in control group is lower than other groups on days 3 and the PVR stage in group 3 is higher than other groups on days 28. In conclusions, intravitreal injected retinoic acid cannot inhibit PVR proliferation on 0.05 and mg/0.1ml concentration and it had toxic effect on retina in 0.1mg/0.1ml concentration. This results may present the lower limit of concentration to use retinoic acid intravitreously.

Keyword

Experimentally induced proliferative vitreoretinopathy; Human retinal pigment epithelium, Intravitreal injection; Retinoic acid

MeSH Terms

Dimethyl Sulfoxide
Epithelial Cells
Epithelium*
Humans*
Intravitreal Injections*
Rabbits*
Retina
Retinal Pigment Epithelium
Retinaldehyde*
Tretinoin*
Vitreoretinopathy, Proliferative*
Dimethyl Sulfoxide
Retinaldehyde
Tretinoin