J Korean Pediatr Soc.  2000 Jul;43(7):959-966.

Effect of Growth Hormone Secretion on Serum Concentration of Leptin

• Kim SE
• Lee JN
• Nam SO
• Chung WY

Abstract

PURPOSE: To investigate the effect of growth hormone(GH) secretion on serum concentration of leptin, we evaluated the differences in serum concentration of leptin between patients with growth hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the relationship between GH and serum leptin level. Also, we analyzed the correlation between serum concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth factor binding protein-3(IGFBP-3), total cholesterol(TC), free fatty acid(FFA) and body mass index(BMI).
METHODS
Eight cases with GHD and 10 cases with GH normal short stature were included in this study. Patients were all male, prepubertal children with mean age 10.6 years. Blood samples were collected in these patients by L-dopa GH provocation test. Statistical analysis of the comparisons of serum leptin level and correlation of multiple variables were performed using PC-SAS program. Significance was defined as P<0.05.
RESULTS
The mean serum concentration of leptin in GHD(12.27+/-10.63ng/mL) was significantly higher than in GH normal short stature(5.39+/-3.21ng/mL)(P=0.0344). Serum concentration of leptin was negatively correlated to GH(y=-7.7x+43.3, r=-0.23, P=0.0109). Serum concentration of leptin was positively correlated to BMI(y=2.5x-33.3, r=0.75, P=0.0003). Serum concentration of leptin was not correlated to IGF-I, IGFBP-3, TC and FFA.
CONCLUSION
Serum concentration of leptin was siginificantly increased in patients with GHD compared to GH normal short stature and was negatively correlated to GH.

Keyword

Serum leptin; Growth hormone; Growth hormone deficiency; L-dopa GH provocation test

MeSH Terms

Child
Growth Hormone*
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Leptin*
Levodopa
Male
Growth Hormone
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Leptin
Levodopa