J Korean Pediatr Soc.  1997 Jul;40(7):1004-1009.

A Case of Epstein-Barr Virus-Associated Hemophagocytic Syndrome Demonstrated by In Situ Hybridization

• Koh DK
• Lee SJ

Abstract

The virus-associated hemophagocytic syndrome is a disorder characterized by a benign, generalized histiocytic proliferation, with marked hemophagocytosis associated with systemic viral infections. We experienced a case of Epstein-Barr virus (EBV)-associated hemophagocytic syndrome in a 2-year-old female who admitted to our department of pediatrics because of high fever, abdominal distension. Evidence for acute, primary EBV infection was demonstrated with serological and in situ hybridization method. Her presentation, treatment, and clinical course are discussed.

Keyword

Hemophagocytic syndrome; Epstein-Barr virus; In situ hybridization

MeSH Terms

Child, Preschool
Epstein-Barr Virus Infections
Female
Fever
Herpesvirus 4, Human
Humans
In Situ Hybridization*
Lymphohistiocytosis, Hemophagocytic*
Pediatrics