J Korean Pediatr Soc.
1996 Aug;39(8):1162-1167.
A Case of Combined Congenital Deficiency of Factor V and Factor VIII
- Affiliations
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- 1Department of Pediatrics, Seoul Adventist Hospital, Seoul, Korea.
Abstract
- Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, post-traumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are different from hemophilia A only with prolonged PTT. We experienced a case of combined congenital deficiency of factor V and factor VIII in a 1-day-old boy. We report the case with brief review of literature.