J Korean Pediatr Soc.  1996 Aug;39(8):1162-1167.

A Case of Combined Congenital Deficiency of Factor V and Factor VIII

• Cho KC
• Lee SK
• Kim IK
• Sung H
• Choi CH

Abstract

Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, post-traumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are different from hemophilia A only with prolonged PTT. We experienced a case of combined congenital deficiency of factor V and factor VIII in a 1-day-old boy. We report the case with brief review of literature.

Keyword

Bleeding disorders; Factor V deficiency; Factor VIII deficiency; Hemorrhagic disease of newborn

MeSH Terms

Blood Coagulation
Factor V Deficiency
Factor V*
Factor VIII*
Hemophilia A
Hemorrhage
Humans
Male
Partial Thromboplastin Time
Prothrombin Time
Tooth Extraction
Vitamin K Deficiency Bleeding
Factor V
Factor VIII