J Korean Rheum Assoc.  2010 Sep;17(3):283-288.

A Case of Wegener's Granulomatosis Presenting with Cerebral Infarction and Intracerebral Hemorrhage

• Ha YJ
• Lee KH
• Jung SY
• Park HS
• Lee SK
• Park YB

Abstract

Wegener's granulomatosis is a multisystem necrotizing vasculitis that primarily involves the upper and lower respiratory tract and kidneys but can affect almost any organ, including the central nervous system. Cerebral infarction and intracerebral hemorrhage are rare neurologic complications of Wegener's granulomatosis. We report on a 52-year-old male patient with Wegener's granulomatosis presenting with a cerebral infarction and subsequent intracerebral hemorrhage. He was successfully treated with high dose corticosteroid and cyclophosphamide.

Keyword

Wegener's granulomatosis; Cerebral infarction; Intracerebral hemorrhage

MeSH Terms

Central Nervous System
Cerebral Hemorrhage
Cerebral Infarction
Cyclophosphamide
Humans
Kidney
Male
Middle Aged
Respiratory System
Vasculitis
Wegener Granulomatosis
Cyclophosphamide

Figure

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  Fig. 1. Magnetic resonance imaging of the brain revealed an acute infarction in the left centrum semiovale and left basal ganglia (A, B), and magnetic resonance angiography of the brain was negative (C).

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  Fig. 2. Brain computed tomography scan showed acute intracerebral hemorrhage in the right frontal lobe, extending into the ventricles.

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  Fig. 3. Paranasal sinus computed tomography showed polypoid mucosal swelling and infiltration in the entire sinonasal cavity and an irregular infiltrative lesion in the right inferomedial orbit, suggesting chronic granulomatous disease involvement (A: transverse view, B: coronal view).

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