J Korean Rheum Assoc.  2009 Dec;16(4):301-305.

A Case of Resistant Polymyositis That Was Successfully Treated with Tacrolimus

  • 1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
  • 2Department of Internal Medicine, The Hospital for Rheumatic Diseases, College of Medicine, Hanyang University, Seoul, Korea. thkim@hanyang.ac.kr
  • 3Department of Pathology, Gachon Medical School, Incheon, Korea.


Polymyositis is one form of inflammatory myopathy. In some patients, this disease does not entirely respond to conventional initial therapy with glucocorticoid, methotrexate and azathioprine. Multiple options exist for treating these patients, but only intravenous immune globulin has been subjected to a randomized clinical trial. We report here on a case of polymyositis that did not respond to multiple drug therapy, but it did respond to tacrolimus. After treatment with tacrolimus, the patient's disease has been well controlled for many years.


Polymyositis; Tacrolimus; Inflammatory myopathy
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