J Korean Rheum Assoc.  2007 Dec;14(4):363-368.

Overlap Syndrome of Amyopathic Antisynthetase Syndrome and Systemic Lupus Erythematosus: A Case Report

• Ko SY
• Seo TH
• Lee SM
• Jang YM
• Kim HR
• Lee SH

Abstract

Interstitial lung disease (ILD) with autoantibodies against antisynthetase may occur in the absence of clinically apparent myositis. We report 58-year-old woman who initially presented with dyspnea. The patient showed positive immunologic markers reflecting systemic lupus erythematosus, destructive polyarthritis, Raynaud's phenomenon, and ILD. There is no proximal muscle weakness in her symptoms. This syndrome was confirmed by positive antibodies to Jo-1. For the early diagnosis of this syndrome, the possibility of this syndrome including other connective tissue disease should be considered in patients presenting with symptoms related to ILD and positive anti-nuclear antibody.

Keyword

Atnisynthetase syndrome; Anti-Jo-1 antibody; Interstitial lung diseases; Systemic lupus erythematosus

MeSH Terms

Antibodies
Arthritis
Autoantibodies
Biomarkers
Connective Tissue Diseases
Dyspnea
Early Diagnosis
Female
Humans
Lung Diseases, Interstitial
Lupus Erythematosus, Systemic*
Middle Aged
Muscle Weakness
Myositis
Antibodies
Autoantibodies

Figure

• 

  Fig. 1. Shortening of digits with deformity of distal interphalangeal joints was showed on both hands.

• 

  Fig. 2. Simple radiographs of both hands show that periarticular osteopenia, joint space narrowing, erosion with destruction in both distal interphalangeal joints.

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  Fig. 3. Plain radiography of chest (A) and high resolution computed tomography of lung (B) demonstrate interstitial infiltrates, bullae and the honeycombing appearance on whole lung fields.

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