J Korean Geriatr Psychiatry.  2014 Oct;18(2):76-80. 10.0000/jkgp.2014.18.2.76.

Association between Cognitive Subdomains and Insight in Alzheimer Disease: A Clinical Research Center for Dementia of South Korea Study

Affiliations
  • 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
  • 2Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea.
  • 3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 5Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 6Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.
  • 7Department of Neurology, Inha University School of Medicine, Incheon, Korea.
  • 8Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVE
The aim of this study was to investigate the association between cognitive subdomains and insight into one's cognitive impairment in patients with Alzheimer disease (AD).
METHODS
We recruited 1,722 patients with AD from the Clinical Research of Dementia of South Korea study and designed a cross-sectional study. Each patient's cognitive subdomain was assessed by using the Seoul Neuropsychological Screening Battery-Dementia version. Severity of dementia was evaluated by Korean version of Mini-Mental Status Examination (K-MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB). Insight into one's cognitive impairment was categorized as 'with insight' and 'without insight' through interview with patient's caregivers.
RESULTS
Among the 1,722 patients with AD, 1,475 patients were included in the 'with insight' group and the remaining 247 patients were included in the 'without insight' group. Subjects in the 'without insight' group had lower K-MMSE and CDR-SB scores than those in the 'with insight' group. After controlling for demographic data and dementia severity, higher scores on both attention function (odds ratio=1.12, 95% confidence interval : 1.03-1.21) and frontal-executive function (odds ratio=1.03, 95% confidence interval : 1.01-1.05) significantly predicted the membership to 'with insight' group.
CONCLUSION
In patients with AD, attention and frontal-executive function were associated with insight into one's cognitive impairment.

Keyword

Alzheimer disease; Dementia; Cognitive function; Insight
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