J Korean Geriatr Psychiatry.  2014 Oct;18(2):69-75. 10.0000/jkgp.2014.18.2.69.

Alcohol Consumption as Risk Factor for Progression from Mild Cognitive Impairment to Dementia : A Clinical Research Center for Dementia of South Korea Study

Affiliations
  • 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. paulkim@skku.edu
  • 2Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, Korea.
  • 3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 5Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 6Department of Neurology, Konkuk University School of Medicine, Seoul, Korea.
  • 7Department of Neurology, Inha University School of Medicine, Incheon, Korea.
  • 8Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.

Abstract


OBJECTIVE
Patients with mild cognitive impairment (MCI) are at high risk for dementia. Excessive alcohol consumption is known to adversely affect cognitive function. This study aimed to investigate the relationship between alcohol consumption and the risk for dementia in a cohort of MCI patients.
METHODS
Participants (n=416) with (MCI) who met Petersen's criteria were recruited from a nationwide, prospective cohort study of dementia and were followed for a median of 17.52 months (range 5.4-63.48). Alcohol consumption was evaluated at baseline.
RESULTS
One hundred twenty seven individuals (30.5%) developed incident dementia (115 Alzheimer disease) during follow-up. Patients with current alcohol consumption at baseline had a higher rate of progression to Alzheimer's dementia than those without current alcohol consumption (hazard ratio 1.61 ; 95% confidence interval 1.03 to 2.53).
CONCLUSION
Alcohol consumption may increase the risk of progression to Alzheimer's dementia in patients with MCI.

Keyword

Alzheimer disease; Alcohol; Mild cognitive impairment
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