J Korean Diabetes Assoc.  1998 Sep;22(3):338-343.

High Serum Lipoprotein ( a ) Levels in Korean Type 2 Diabetic Patients with Proliferative Diabetic retinopathy

• Park HJ
• Kim CH
• Chung YE
• Kim SW
• Kim JY
• Kim ES
• Hong SK
• Lee KU

Abstract

BACKGROUND: To examine the possible association between serum lipoprotein(a) (Lp(a)) concentration and proliferative diabetic retinopathy(PDR) in Korean patients with type 2 diabetes mellitus. METHODS: A total of 412 Korean outpatients with type 2 diabetes were examined. Diabetic retinopathy was determined by fundoscopic examination by an ophthalmologist and/or by fluorecein angiography. Semm Lp(a) levels were measured by one step sandwich ELISA method. RESULTS: The patient with PDR had higher serum Lp(a) levels than those with no retinopathy or non-proliferative diabetic retinopathy(NPDR). Multiple logistic regression analysis showed that serum Lp(a) level and the presence of diabetic nephropathy were independent variables having a statistically significant association with PDR. CONCLUSION: Korean type 2 diabetic patients with PDR had higher serum Lp(a) levels compared with those with no retinopathy or NPDR. Although these results suggested that Lp(a) might play a role in the occlusion of retinal capillaries leading to PDR, further prospective studies are required to prove causal relationship.

Keyword

Proliferative diabetic retinopathy; Lipoprotein(a); Korean; Type 2 diabetes

MeSH Terms

Angiography
Capillaries
Diabetes Mellitus, Type 2
Diabetic Nephropathies
Diabetic Retinopathy*
Enzyme-Linked Immunosorbent Assay
Humans
Lipoprotein(a)
Lipoproteins*
Logistic Models
Outpatients
Retinaldehyde
Lipoprotein(a)
Lipoproteins
Retinaldehyde