J Korean Cancer Assoc.  1998 Jun;30(3):475-481.

5-Fluorouracil , Cisplatin , and Pirarubicin Combination Chemotherapy for Advanced Gastric Cancer

Affiliations
  • 1Department of Internal Medicine, Korea University College of Medicine, Seoul Korea.
  • 2Department of Surgery, Korea University College of Medicine, Seoul Korea.

Abstract

PURPOSE
Gastric cancer is the most common malignacy in Korea, However, standard systemic combination chemotherapy regimen has not been settled for advanced gastric cancer. 5-FU, Cisplatin, and Pirarubicin combination chemotherpay regimen has been tried to evaluate the response rate and toxicity in advanced gastric cancer patients.
MATERIALS AND METHODS
Elligibility included biopsy proven inoperable or relapsed adenocarcinoma of stomach with adequate bone marrow, hepatic, and renal functon. Thirty seven patients with histologically confinned locally advanced or metastatic gastric cancer were treated with cisplatin 15 mg/m2 IV day 1~5, pirarubicin 60 mg/m2 day 1, 5-fluorouracil 750 mg/m2 day 1~5 as a continuous intravenous infusion.
RESULTS
Twenty nine patients had measurable disease, 5 had received prior chemotherapy. Performance status was 0~1 in 24 and 2 in 13. There was 1 complete response and 13 partial response with an overall response rate of 48.3%(95% confidence interval 29.9~67.1%). The median survival is 7 months(95% confidence interval 5.4~8.6 months) and median response duration is 6 months. 19 patients experienced severe(WHO grade 3~4) leucopenia, 7 was thrombocytopenia, 13 was nausea and vomiting during chemotherapy. 11 patients experienced chemotherapy dose reduction or chemotherapy time delay due to severe hematologic or non-hematologic toxicities. There was no clinically recognizable cardiac toxicities.
CONCLUSION
We experienced 48.3% overall response rate, 7 months median survival, and 51.3% severe hematologic toxicities with 5-fluorouracil, pirarubicin and cisplatin combination chemotherapy regimen in advanced or metastatic gastric cancer patients.

Keyword

Gastric cancer; Pirarubicin; Cisplatin

MeSH Terms

Adenocarcinoma
Biopsy
Bone Marrow
Cisplatin*
Drug Therapy
Drug Therapy, Combination*
Fluorouracil*
Humans
Infusions, Intravenous
Korea
Nausea
Stomach
Stomach Neoplasms*
Thrombocytopenia
Vomiting
Cisplatin
Fluorouracil
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