J Korean Soc Laryngol Phoniatr Logoped.  2016 Jun;27(1):5-10. 10.0000/jkslpl.2016.17.1.5.

The Management of Systemic Voice Disorders

• Woo JH

• KMID: 2328910
• DOI: http://doi.org/10.0000/jkslpl.2016.17.1.5

Abstract

Variable systemic diseases affect larynx and vocal fold and result in voice change. Asthma and chronic obstructive pulmonary disease make increase of intra-abdomimal pressure followed by reflux of gastric acid, which stimulate vagal-bronchopulomary reflex aggravating cough and respiratory disturbance. Fungal laryngitis in the general population is extremely rare, but can occur in immunocompromised AIDS patients. Although, initially, empirical antifungal therapy for candidiasis is often given without biopsy, diagnostic direct laryngoscopy and biopsy is imperative if a substantial clinical response is not rapidly achieved. In the highly active anti-retroviral therapy era, HIV-positive patients are living longer and are at higher risk for developing non-AIDS-defining malignancies. The incidence of head and neck cancer (HNC) which is related with human papilloma virus infection has increased. The survival is significantly lower among the AIDS-HNC patients with CD4 counts ≤200 cells/µL. Rheumatoid arthritis (RA) cause voice disturbance by developing cricoarytenoid joints fixation or nodule on vocal fold. Post-menopausal voice disorder (PMVD) is caused by decreased secretion of estrogen-progesterone resulting in decrease of fundamental frequency (F0). Hormonal replacement therapy is helpful to reduce F0 decrease. RA and PMVD result in slight voice change, but it could crucial in professional voice user.

Keyword

Systemic; Disease; Voice disorders

MeSH Terms

Arthritis, Rheumatoid
Asthma
Biopsy
Candidiasis
CD4 Lymphocyte Count
Cough
Gastric Acid
Head and Neck Neoplasms
Humans
Incidence
Joints
Laryngitis
Laryngoscopy
Larynx
Papillomaviridae
Pulmonary Disease, Chronic Obstructive
Reflex
Vocal Cords
Voice Disorders*
Voice*