Nat Prod Sci.  2016 Jun;22(2):129-133. 10.20307/nps.2016.22.2.129.

Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production

• Park TW
• Lee C
• Lee JW
• Jang H
• Jin Q
• Lee MK
• Hwang BY

• KMID: 2328879
• DOI: http://doi.org/10.20307/nps.2016.22.2.129

Abstract

Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.

Keyword

Buddleja officinalis; Buddlejaceae; NO production inhibitor

MeSH Terms

Buddleja*
Lignans
Methanol
Monoterpenes
Nitric Oxide*
RAW 264.7 Cells
Saponins
Statistics as Topic
Lignans
Methanol
Monoterpenes
Nitric Oxide
Saponins

Figure

• 

  Fig. 1. Structures of 1–8 isolated from B. officinalis.

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