J Korean Diabetes.  2016 Jun;17(2):112-116. 10.4093/jkd.2016.17.2.112.

Micronutrients and Diabetes Mellitus: The Role of Chromium

Affiliations
  • 1Department of Food and Nutrition, Suwon Women's University, Hwaseong, Korea. jhkang@swc.ac.kr

Abstract

Chromium (Cr) is a mineral that humans require in trace amounts, however its mechanisms of action in the body and the exact amounts needed for optimal health are not well defined. Cr has long been of interest for its possible connection to various health conditions. Among the most active areas of Cr research is for its use in supplement form to treat diabetes, lower blood lipid levels, promote weight loss, and improve body composition. However, controversy exists as to whether dietary supplementation with Cr should be routinely recommended in subjects. In this paper, we will review the favorable effects of Cr supplementation on glycemic control in patients with diabetes.

Keyword

Chromium; Diabetes mellitus; Insulin resistance

MeSH Terms

Body Composition
Chromium*
Diabetes Mellitus*
Dietary Supplements
Humans
Insulin Resistance
Micronutrients*
Miners
Weight Loss
Chromium
Micronutrients

Reference

References

1. World Health Organization. World Health Day 2016: WHO calls for global action to halt rise in and improve care for people with diabetes. Available from:. http://www.who.int/mediacentre/news/releases/2016/world-health-day/en/. (updated 2016 Apr 6).
2. Korea National Health and Nutrition Examination Survey. Korea Health Statistics 2014. Cheongju: Korea National Health and Nutrition Examination Survey (KNHANES VI-2);2014. p. 54–5.
3. Anderson RA. Chromium, glucose tolerance, diabetes and lipid metabolism. J Adv Med. 1995; 8:37–50.
4. Anderson RA, Polansky MM, Bryden NA, Patterson KY, Veillon C, Glinsmann WH. Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters. J Nutr. 1983; 113:276–81.
Article
5. Lim TH, Sargent T 3rd, Kusubov N. Kinetics of trace element chromium (III) in the human body. Am J Physiol. 1983; 244:R445–54.
6. Kozlovsky AS, Moser PB, Reiser S, Anderson RA. Effects of diets high in simple sugars on urinary chromium losses. Metabolism. 1986; 35:515–8.
Article
7. Lukaski HC, Bolonchuk WW, Siders WA, Milne DB. Chromium supplementation and resistance training: effects on body composition, strength, and trace element status of men. Am J Clin Nutr. 1996; 63:954–65.
Article
8. Davies S, McLaren Howard J, Hunnisett A, Howard M. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients–implications for the prevention of cardiovascular disease and type II diabetes mellitus. Metabolism. 1997; 46:469–73.
Article
9. Hopkins LL Jr, Schwarz K. Chromium (3) binding to serum proteins, specifically siderophilin. Biochim Biophys Acta. 1964; 90:484–91.
10. Abraham AS, Brooks BA, Eylath U. The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulindependent diabetes. Metabolism. 1992; 41:768–71.
Article
11. Wang ZQ, Cefalu WT. Current concepts about chromium supplementation in type 2 diabetes and insulin resistance. Curr Diab Rep. 2010; 10:145–51.
Article
12. Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A. Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving longterm total parenteral nutrition. Am J Clin Nutr. 1977; 30:531–8.
Article
13. Brown RO, Forloines-Lynn S, Cross RE, Heizer WD. Chromium deficiency after longterm total parenteral nutrition. Dig Dis Sci. 1986; 31:661–4.
Article
14. Abraham AS, Sonnenblick M, Eini M. The action of chromium on serum lipids and on atherosclerosis in cholesterol-fed rabbits. Atherosclerosis. 1982; 42:185–95.
Article
15. Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998; 56:266–70.
Article
17. Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. 1997; 46:1786–91.
Article
18. Feng J, Lin D, Zheng A, Cheng N. Chromium picolinate reduces insulin requirement in people with type 2 diabetes mellitus [abstract]. Diabetes. 2002; 51:A469.
19. Rabinovitz H, Friedensohn A, Leibovitz A, Gabay G, Rocas C, Habot B. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res. 2004; 74:178–82.
Article
20. Ravina A, Slezak L, Rubal A, Mirsky N. Clinical use of the trace element chromium (III) in the treatment of diabetes mellitus. J Trace Elem Med. 1995; 8:183–90.
21. Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review. Diabetes Technol Ther. 2006; 8:677–87.
Article
22. Lindemann MD. Organic chromium-the missing link in farm animal nutrition? Feeding Times. 1996; 1:8–16.
23. Kleefstra N, Houweling ST, Jansman FG, Groenier KH, Gans RO, Meyboom-de Jong B, Bakker SJ, Bilo HJ. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care. 2006; 29:521–5.
24. Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care. 1994; 17:1449–52.
Article
25. Jeejeebhoy KN. The role of chromium in nutrition and therapeutics and as a potential toxin. Nutr Rev. 1999; 57:329–35.
Article
26. Flodin NW. Micronutrient supplements: toxicity and drug interactions. Prog Food Nutr Sci. 1990; 14:277–331.
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