J Korean Assoc Oral Maxillofac Surg.  2010 Oct;36(5):386-391.

Expression of osteoclastogenesis related factors in dental implant patients

• Ryu SH
• Kim BS
• Jung S
• Han MS
• Kook MS
• Ohk SH
• Oh HK
• Park HJ

Abstract

INTRODUCTION
Bone resorption is a unique function of osteoclasts. Osteoclasts are a specialized macrophage polykaryon whose differentiation is regulated principally by macrophage colony-stimulating factors, receptor activator of nuclear factor kappaB ligand (RANK) ligand, osteoprotegerin (OPG), and interleukins (IL). Reflecting the integrin-mediated signals, osteoclasts develop a specialized cytoskeleton that allows it to establish an isolated micro-environment between itself and the bone, wherein matrix degradation occurs by a process involving proton transport. The levels of IL-1, IL-6, OPG, and prostaglandin E2 (PGE2) expression were evaluated to study the correlations between dental implant teeth and the adjacent teeth.
MATERIALS AND METHODS
The exudate of the gingival crevice acquired from dental implants, adjacent teeth, opposite teeth and contralateral teeth of 24 patients.
RESULTS
1. The levels of IL-1, IL-6, OPG and PGE2 expression in dental implant teeth were higher than those of the contralateral teeth. 2. IL-1 revealed a higher expression level in the adjacent teeth than in dental implant teeth. 3. The dental implant teeth and adjacent teeth did not show a remarkable difference in the level of IL-1 expression. 4. All the other cytokines were strongly expressed in the dental implant compared to the adjacent teeth.
CONCLUSION
These results suggest that there might be close correlation between dental implant teeth and adjacent teeth in terms of the expressions of cytokines that affect the development and regulation of osteoclasts.

Keyword

Dental implants; Cytokines; Osteoclasts

MeSH Terms

Bone Resorption
Cytokines
Cytoskeleton
Dental Implants
Dinoprostone
Exudates and Transudates
Humans
Interleukin-1
Interleukin-6
Interleukins
Macrophage Colony-Stimulating Factor
Macrophages
Osteoclasts
Osteoprotegerin
Protons
RANK Ligand
Tooth
Cytokines
Dental Implants
Dinoprostone
Interleukin-1
Interleukin-6
Interleukins
Macrophage Colony-Stimulating Factor
Osteoprotegerin
Protons
RANK Ligand

Figure

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  Fig. 1. Expression of interleukin-1 α(IL-1 α) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth)

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  Fig. 2. Expression of interleukin-1 β(IL-1 β) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

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  Fig. 3. Expression of interleukin-6 (IL-6) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth)

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  Fig. 4. Expression of osteoprotegerin (OPG) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

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  Fig. 5. Expression of prostaglandin E2 (PGE2) in dental implant patients. (I: dental implant teeth, A: adjacent teeth to the dental implant, O: opposite, N: normal teeth. 1: P<0.01, 2: P<0.01)

Reference

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