J Korean Assoc Oral Maxillofac Surg.  2006 Aug;32(4):374-379.

Central granular cell odontogenic tumor(CGCOT): A case report including light microscopy, immunohistochemistry and literature review

Affiliations
  • 1department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung-Pook National University, Korea.
  • 2department of Dentistry, Ulsan University Hospital, Korea.

Abstract

Central granular cell odontogenic tumor(CGCOT) is a very rare lesion that consists of densely packed granular cells with numerous scattered strands of odontogenic epithelium interspersed throughout the tissue. CGCOT was initially reported in 1962 by Cough et al as central granular cell ameloblastic fibroma. But, recently, this term is inappropriate because of histologic and chronologic differences. CGCOT is usually present as painless swellings. Radiographs show a well-demarcated radiolucent or mixed radiopaque-radiolucent lesion. The average age on presentation of CGCOT is 47.3 and women are 75% more likely to develop this lesion than men. The tumor only occur in tooth bearing areas of the jaw with 88% of cases occurring in the mandible and 12% involving the maxilla, usually in an equal distribution between the caninepremolar-molar areas. This tumor is benign, and care is effected by localized surgical excision. We report an additional case of CGCOT that occurred in the Rt. Maxillar premolar/molar region of a 32-year old man with literature review.

Keyword

Central granular cell odontogenic tumor

MeSH Terms

Adult
Ameloblasts
Cough
Epithelium
Female
Fibroma
Humans
Immunohistochemistry*
Jaw
Male
Mandible
Maxilla
Microscopy*
Tooth
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