J Korean Androl Soc.  1993 Dec;11(2):129-134.

A Case Of Male Infertility Secondary To Congenital Adrenal Hyperplasia

  • 1Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
  • 2Department of Urology, Seoul City Boramae Hospital, Seoul, Korea.


Congenital adrenal hyperplasia, a deficiency of an adrenal enzyme involved in the biosynthesis of cortisol, is a recognized cause of infertility. Abnormal adrenal steroid production inhibits the release of gonadotropins by the hypothalamic-hypophyseal axis, resulting in failure of normal testicular maturation. We have studied a male patient with congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency who presented with infertility. After he had received 7 weeks of steroid treatment, his wife became pregnant. Suppression of gonadotropin secretion due to overproduction of adrenal androgens would appear to be the reason for the failure of testicular maturation and spermatogenesis in this patient. We conclude that glucocorticoid treatment is indicated in infertile men suffering from congenital adrenal hyperplasia and that late-onset congenital adrenal hyperplasia should be suspected in any male infertility of unknown origin.

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