Korean J Intern Med.  2016 Jul;31(4):653-659. 10.3904/kjim.2014.313.

Is height a risk factor for colorectal adenoma?

Affiliations
  • 1Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. bowelkim@gmail.com

Abstract

BACKGROUND/AIMS
Although it is generally known that the risk for all types of cancer increases with adult height, combined and for several common site-specific cancers (including colon and rectal), evidence is limited for adenomas, which are precursors to colorectal cancer. We evaluated the association between height and risk of colorectal adenoma at various stages of the adenoma-carcinoma pathway.
METHODS
We conducted a retrospective study using data from patients who had undergone a complete colonoscopy as part of a health examination at the Health Promotion Center of Samsung Medical Center between October 13, 2009 and December 31, 2011. A total of 1,347 male subjects were included in our study. Multivariate logistic regression analysis was used to evaluate the association between height and colorectal adenoma.
RESULTS
Each 5-cm increase in height was associated with 1.6% and 5.3% higher risks of advanced colorectal adenoma and high-risk colorectal adenoma, respectively, but associations were not significant after adjusting for age, body mass index, metabolic syndrome, alcohol intake, smoking, family history of colorectal cancer, and regular aspirin use (p = 0.840 and p = 0.472, respectively).
CONCLUSIONS
No clear association was found between colorectal adenoma risk and height. Unlike other site-specific tumors reported to have a consistent relationship with height, the association between colorectal tumor and height remains controversial.

Keyword

Body height; Colorectal adenoma; Colorectal neoplasms; Body weight

MeSH Terms

Adenoma*
Adult
Aspirin
Body Height
Body Mass Index
Body Weight
Colon
Colonoscopy
Colorectal Neoplasms
Health Promotion
Humans
Logistic Models
Male
Retrospective Studies
Risk Factors*
Smoke
Smoking
Aspirin
Smoke
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