Exp Mol Med.  2016 Jan;48(1):e201. 10.1038/emm.2015.93.

The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance

  • 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, Korea. msyoon@gachon.ac.kr
  • 2Korea Mouse Metabolic Phenotyping Center (KMMPC), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
  • 3Department of Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.


Mammalian target of rapamycin (mTOR) controls cell growth and metabolism in response to nutrients, energy, and growth factors. Recent findings have placed the lysosome at the core of mTOR complex 1 (mTORC1) regulation by amino acids. Two parallel pathways, Rag GTPase-Ragulator and Vps34-phospholipase D1 (PLD1), regulate mTOR activation on the lysosome. This review describes the recent advances in understanding amino acid-induced mTOR signaling with a particular focus on the role of mTOR in insulin resistance.

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