J Neurogastroenterol Motil.  2010 Jul;16(3):319-322.

A Case of Amyotrophic Lateral Sclerosis Presented as Oropharyngeal Dysphagia

  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. mipark@ns.kosinmed.or.kr


Amyotrophic lateral sclerosis is a rare disease. It is a fatal neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons which leads to muscle weakness and muscle wasting. Respiratory failure limits survival to 2-5 years after disease onset. Several clinical manifestations including dysphagia can result in reductions in both the quality of life and life expectancy. Dysphagia occurs at onset in about one third of case, although generally it occurs in later stage of the disease. Evaluation of dysphagia includes video-fluoroscopic swallow study, radiological esophagogram, flexible endoscopic examination, ultrasound examination, conventional manometry and electromyography. We report a case of amyotrophic lateral sclerosis in a 54-year-old man presenting oropharyngeal dysphagia which was diagnosed by high resolution esophageal manometry presenting abnormality of the upper esophageal sphincter.


Oropharyngeal dysphagia; Amyotrophic lateral sclerosis; High resolution manometry
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