J Neurogastroenterol Motil.  2011 Oct;17(4):395-401.

Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)

• Sakamoto Y
• Sekino Y
• Yamada E
• Ohkubo H
• Higurashi
• Sakai E
• Iida H
• Hosono K
• Endo H
• Nonaka T
• Ikeda T
• Fujita K
• Yoneda M
• Koide T
• Takahashi
• Goto A
• Abe Y
• Gotoh E
• Maeda S
• Nakajima A
• Inamori M

Abstract

BACKGROUND/AIMS
The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still remains controversial whether high-viscosity liquid meals have any effect on the rate of gastric emptying. The present study was conducted with the aim of determining whether high-viscosity liquid meals had any effect on the rate of gastric emptying and mosapride might accelerate the rate of gastric emptying of high-viscosity liquid meals.
METHODS
Six healthy male volunteers underwent 3 tests at intervals of > 1 week. After fasting for > 8 hours, each subject received one of three test meals (liquid meal only, high-viscosity liquid meal [liquid meal plus pectin] only, or high-viscosity liquid meal 30 minutes after intake of mosapride). A 13C-acetic acid breath test was performed, which monitored the rate of gastric emptying for 4 hours. Using the Oridion Research Software (beta version), breath test parameters were calculated. The study parameters were examined for all the 3 test conditions and compared using the Freidman test.
RESULTS
Gastric emptying was significantly delayed following intake of a high-viscosity liquid meal alone as compared with a liquid meal alone; however, intake of mosapride prior to a high-viscosity liquid meal was associated with a significantly accelerated rate of gastric emptying as compared with a high-viscosity liquid meal alone.
CONCLUSIONS
This study showed that high-viscosity liquid meals delayed gastric emptying: however, mosapride recovered the delayed rate of gastric emptying by high-viscosity liquid meals.

Keyword

Breath test; Gastric emptying; Mosapride; Pectin

MeSH Terms

Benzamides
Breath Tests
Cross-Over Studies
Fasting
Gastric Emptying
Gastroesophageal Reflux
Humans
Male
Meals
Morpholines
Pectins
Benzamides
Morpholines
Pectins